In Vivo Infection Models and Common Mistakes When Choosing Them Common mistakes in selecting in vivo models for antimicrobial testing include inappropriate inoculum size, which can exaggerate or mask drug effects; inadequate drug exposure at the infection site,...
The Cecal Ligation and Puncture (C.L.P.) model is a widely used in vivo method for inducing polymicrobial sepsis in mice. By surgically ligating and puncturing the cecum, the model closely replicates key aspects of human sepsis and is commonly used to evaluate disease...
The cost of an in vivo infection model is influenced by several key variables, including the number and strain of animals used, housing requirements, study duration, dosing routes, and the type and frequency of data collected. Each of these factors impacts labor,...
Small Molecule Drug Discovery Small Molecule Drug Discovery Recent research headlines have placed a heavy focus on biologics, but small molecule discovery is still dominating the pharmaceutical R&D space. In fact, 62% of new drug approvals in 2021 were for small...
Targetting “Undruggable” Proteins Targetting “Undruggable” Proteins A protein called Med25, found in human breast cancer cells, was notoriously undruggable. As a transcriptional coactivator, the protein influences gene activation by using its...
Laser Kills Bacteria Laser Kills Bacteria With bacterial resistance a growing concern, scientists are searching for alternatives to antibiotics. Recently, researchers at the Washington University School of Medicine in St. Louis, Missouri discovered a type of laser...
