In Vivo Models
More than 100 validated infection models, each customized to your compound and endpoints. When in vitro data shows promise, this is where it becomes biological proof.
The Efficacy Layer
Translating Bench Activity Into Biological Proof
Our in vivo models span nearly every anatomical site and infection type relevant to antimicrobial development. Each is run in our AAALAC-accredited facility and tailored to your compound, route, dosing, and readouts.
Select a model below, or talk to us about developing one you don’t see listed. Pharmacokinetic profiling, blood chemistry, tissue harvests, and histopathology are available as add-ons to any in vivo study.
Acute and chronic lung infection models for evaluating compounds against respiratory pathogens.
Bloodstream infection models measuring systemic bacterial burden and survival.
Disseminated fungal infection models for antifungal efficacy evaluation.
Cecal ligation and puncture polymicrobial sepsis for severe systemic infection.
Intra-abdominal infection models for rapid efficacy screening.
Ascending UTI models evaluating activity against uropathogens.
Bone infection models for compounds targeting deep-seated, hard-to-treat infections.
Wound models assessing efficacy in soft-tissue and surgical-site infection.
Localized dermal infection models for topical and systemic agents.
Surface skin infection models for evaluating topical antimicrobials.
Compromised skin-barrier infection models.
Middle-ear infection models for compounds targeting ENT indications.
CNS infection models for compounds that must cross into the brain.
Deep soft-tissue infection models across multiple anatomical sites.
GI infection models, including C. difficile-associated disease.
In vivo models for Trypanosoma cruzi and antiparasitic compound evaluation.
Localized abscess models for evaluating activity against contained, purulent infection.
In vivo biofilm models for surface-associated, highly resistant infection.
Mucosal infection models for genitourinary and reproductive-tract pathogens.