A “Two-Hit” Model of Sepsis A “Two-Hit” Model of Sepsis TransPharm recently validated a “two-hit” model of sepsis in which mice undergo cecal ligation and puncture (CLP) followed by intranasal instillation with bacteria to initiate...
Cease and Persist? Cease and Persist? After a bacterial infection is established, a small percentage of the bacteria slow their metabolism in response to environmental stressors. This semi-dormant state affords increased tolerance to antibiotics, especially...
Biofilms: Skimming the Surface Biofilms: Skimming the Surface There are two basic forms of microbes: free-floating and anchored. While free-floating microbes are better understood, 90% of all microorganisms are anchored. Anchored microbes have the ability to form...
Trick and Treat Bacteria Trick and Treat Bacteria What do the ancient Greeks and a group of modern-day researchers have in common? Scientists at the University of Washington School of Medicine are using a “Trojan Horse” strategy to trick and treat (Happy Halloween!)...
E. coli in Retail Poultry May Cause UTIs E. coli in Retail Poultry May Cause UTIs Foodborne bacteria are a common cause of gastrointestinal infection, but a recent study found that a strain of E. coli in retail chicken and turkey may be transmitted to humans and cause...
Synergistic Combination Therapy Against Resistant Pathogens Synergistic Combination Therapy Against Resistant Pathogens Due to increasing rates of antimicrobial resistance, scientists are researching the potential of combination therapy (two or more drugs used...
