Dose Ranging Model
Maximum Tolerated Dose (MTD) Studies
Tolerability and dose-ranging studies to define the therapeutic window.
Before efficacy testing, it is essential to understand how much compound can be safely administered. Maximum tolerated dose (MTD) studies establish tolerability and help define the therapeutic window that frames subsequent efficacy work.
These studies provide the dosing foundation on which a sound in vivo program is built.
Applications
- Tolerability assessment
- Dose-range finding
- Therapeutic-window definition
- Support for efficacy study design
Customized to your program
Like all of our in vivo work, this model is tailored to your compound, route of administration, dosing regimen, and the specific endpoints your program requires. We will work with you to design a study that answers your scientific questions and stands up to regulatory scrutiny.