PK/PD Model
Pharmacokinetic / Pharmacodynamic Studies
PK/PD study design linking drug exposure to antimicrobial effect.
Understanding the relationship between drug exposure and antimicrobial effect is essential to rational dosing and successful development. Our PK/PD studies characterize how compound concentrations over time relate to efficacy, identifying the pharmacodynamic drivers of activity.
This work informs dose selection and supports regulatory strategy as a program advances.
Applications
- Exposure–response characterization
- Identification of PK/PD index (Cmax, AUC, time above MIC)
- Dose-fractionation studies
- Dose-selection support
Customized to your program
Like all of our in vivo work, this model is tailored to your compound, route of administration, dosing regimen, and the specific endpoints your program requires. We will work with you to design a study that answers your scientific questions and stands up to regulatory scrutiny.