Animal Welfare: AAALAC, AALAS, & PHS assurance Animal welfare plays a critical role in scientific research, education, and biomedical advancement. Ethical treatment of animals is not only a moral responsibility but also essential for producing reliable, high...
Pneumonia Models for MDR Lung Infections Multidrug-resistant (MDR) lung infections present a growing global health threat, driving urgent demand for better preclinical models. Pneumonia models have emerged as crucial platforms for studying host-pathogen interactions,...
In Vivo Infection Models and Common Mistakes When Choosing Them Common mistakes in selecting in vivo models for antimicrobial testing include inappropriate inoculum size, which can exaggerate or mask drug effects; inadequate drug exposure at the infection site,...
Small Molecule Drug Discovery Small Molecule Drug Discovery Recent research headlines have placed a heavy focus on biologics, but small molecule discovery is still dominating the pharmaceutical R&D space. In fact, 62% of new drug approvals in 2021 were for small...
Targetting “Undruggable” Proteins Targetting “Undruggable” Proteins A protein called Med25, found in human breast cancer cells, was notoriously undruggable. As a transcriptional coactivator, the protein influences gene activation by using its...
