In Vitro Assay
Time-Kill Kinetics Assay
How quickly and how completely your compound reduces a microbial population over time — the shape of the kill.
A time-kill kinetics assay measures the rate and extent of antimicrobial activity over time, revealing how quickly and how completely a compound reduces a microbial population. By sampling at defined intervals, we generate kill curves that characterize the dynamics of activity.
These data distinguish concentration-dependent from time-dependent killing — a fundamental input for rational dosing strategy and a valuable complement to static MIC and MBC endpoints.
Methodology
- Viable counts at defined time intervals
- Multiple compound concentrations
- Kill-curve generation
- Concentration- vs time-dependent characterization
Applications
- Characterizing the rate and extent of kill
- Informing dosing strategy (concentration- vs time-dependent)
- Comparing candidates beyond a single MIC value
- Supporting PK/PD study design
Customized to your program
Every assay is tailored to your compound and your panel of organisms, including the resistant phenotypes most relevant to your program. Contact us to learn more about in vitro efficacy testing of your test article, or to request a free, no-obligation quote.